Abstract |
Rats with a genetic susceptibility to salt hypertension were given repeated neonatal injections of guanethidine. Vascular reactivity and tissue catecholamine concentrations indicated that a peripheral sympathectomy had been produced. Chemically sympathectomized rats had lower blood pressure than controls while fed a diet containing 0.4% NaCl. Furthermore, the dramatic rise in blood pressure exhibited by control rats fed a diet containing 8.0% NaCl was completely absent in sympathectomized rats similarly fed. The absence of salt-induced hypertension was observed regardless of whether the animals were anesthetized with ether or pentobarbital or had the blood pressures determined in an unanesthetized state. Finally, two-kidney Goldblatt hypertension did develop in sympathectomized rats, but to a level below intact rats similarly treated.
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Authors | R Friedman, L M Tassinari, M Heine, J Iwai |
Journal | Clinical and experimental hypertension
(Clin Exp Hypertens (1978))
Vol. 1
Issue 6
Pg. 779-99
( 1979)
ISSN: 0148-3927 [Print] United States |
PMID | 551897
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Catecholamines
- Angiotensin II
- Pentolinium Tartrate
- Norepinephrine
- Tyramine
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Topics |
- Angiotensin II
(pharmacology)
- Animals
- Blood Pressure
(drug effects)
- Catecholamines
(blood)
- Constriction
- Hypertension
(blood, physiopathology)
- Hypertension, Renal
(etiology, physiopathology)
- Male
- Norepinephrine
(pharmacology)
- Pentolinium Tartrate
(pharmacology)
- Rats
- Renal Artery
(physiopathology)
- Sympathetic Nervous System
(drug effects, physiopathology)
- Tyramine
(pharmacology)
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