Differential development of salt-induced and renal hypertension in Dahl hypertension-sensitive rats after neonatal sympathectomy.

Abstract

Rats with a genetic susceptibility to salt hypertension were given repeated neonatal injections of guanethidine. Vascular reactivity and tissue catecholamine concentrations indicated that a peripheral sympathectomy had been produced. Chemically sympathectomized rats had lower blood pressure than controls while fed a diet containing 0.4% NaCl. Furthermore, the dramatic rise in blood pressure exhibited by control rats fed a diet containing 8.0% NaCl was completely absent in sympathectomized rats similarly fed. The absence of salt-induced hypertension was observed regardless of whether the animals were anesthetized with ether or pentobarbital or had the blood pressures determined in an unanesthetized state. Finally, two-kidney Goldblatt hypertension did develop in sympathectomized rats, but to a level below intact rats similarly treated.

• Authors: R Friedman, L M Tassinari, M Heine, J Iwai
• Journal: Clinical and experimental hypertension (Clin Exp Hypertens (1978)) Vol. 1 Issue 6 Pg. 779-99 ( 1979) ISSN: 0148-3927 [Print] United States
• PMID: 551897 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Catecholamines
• Angiotensin II
• Pentolinium Tartrate
• Norepinephrine
• Tyramine

Topics

• Angiotensin II (pharmacology)
• Animals
• Blood Pressure (drug effects)
• Catecholamines (blood)
• Constriction
• Hypertension (blood, physiopathology)
• Hypertension, Renal (etiology, physiopathology)
• Male
• Norepinephrine (pharmacology)
• Pentolinium Tartrate (pharmacology)
• Rats
• Renal Artery (physiopathology)
• Sympathetic Nervous System (drug effects, physiopathology)
• Tyramine (pharmacology)