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Tubules of globoid leukodystrophy: a right-handed helix.

Abstract
Morphologic similarity between the cytoplasmic tubules of globoid leukodystrophy and Gaucher's disease (as demonstrated by thin sectioning, negative staining, and shadowing techniques) and their resemblance to negatively stained beef cerebroside are presented as evidence favoring the accumulation of cerebrosides in globoid cells. The tubules of globoid leukodystrophy have a 60-angstrom periodic banding similar to the tubules of Gaucher's disease. A right-handed helical twisting of the tubules is observed in both diseases.
AuthorsE J Yunis, R E Lee
JournalScience (New York, N.Y.) (Science) Vol. 169 Issue 3940 Pg. 64-6 (Jul 03 1970) ISSN: 0036-8075 [Print] United States
PMID5463179 (Publication Type: Journal Article)
Chemical References
  • Cerebrosides
  • Transferases
Topics
  • Animals
  • Cattle
  • Cerebrosides (metabolism)
  • Diffuse Cerebral Sclerosis of Schilder (pathology)
  • Gaucher Disease (pathology)
  • Humans
  • Lipidoses (pathology)
  • Microscopy, Electron
  • Microtubules
  • Organoids
  • Transferases (metabolism)

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