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Chemically induced porphyria: prevention by prior treatment with phenobarbital.

Abstract
The excessive induction of hepatic delta-aminolevulinic acid synthetase in rats after the administration of porphyria-inducing compounds is prevented by prior treatment with phenobarbital. Studies in vivo and in vitro indicate that phenobarbital prevents the induction of chemical porphyria by increasing the rate of detoxification of inducers by way of drug-metabolizing enzymes of the hepatic endoplasmic reticulum.
AuthorsL Kaufman, A L Swanson, H S Marver
JournalScience (New York, N.Y.) (Science) Vol. 170 Issue 3955 Pg. 320-2 (Oct 16 1970) ISSN: 0036-8075 [Print] United States
PMID5460517 (Publication Type: Journal Article)
Chemical References
  • Amides
  • Amino Acids
  • Carbon Isotopes
  • Levulinic Acids
  • Succinates
  • Progesterone
  • Acyltransferases
  • Phenobarbital
Topics
  • Acyltransferases (biosynthesis)
  • Amides
  • Amino Acids
  • Animals
  • Biotransformation
  • Carbon Isotopes
  • Chromatography, Thin Layer
  • Endoplasmic Reticulum (enzymology)
  • Enzyme Induction (drug effects)
  • Female
  • Levulinic Acids (biosynthesis)
  • Liver (cytology, enzymology)
  • Microsomes, Liver (metabolism)
  • Phenobarbital (therapeutic use)
  • Porphyrias (chemically induced, drug therapy)
  • Progesterone
  • Rats
  • Succinates (biosynthesis)

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