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[The significance of immunological constellation with regard to the development of hypersensitivity against various chemical compounds (author's transl)].

Abstract
Biopon is a generally used detergent containing detergens which does not cause hypersensitivity as was demonstrated by the authors in previous animal experiments. In the present study the authors describe the Haptene character of Biopon which quality could be demonstrated by causing a certain immunological constellation in guinea-pigs on the grounds of a hypothesis. The hypothetical concept consisted in aiding a half-antigen in the organism even in the case of its intradermal injection into a thick immunocompetent cell agglomeration. The authors produced the agglomeration of cells of the skin by means of intradermal injections of alien serum and in with BCG treated animals with tuberculin reaction. Biopon was administered thereafter into the focus by intradermal injection. The presented two aiding methods showed different effects which the authors try to explain by the fact that different adjuvants cause different effects.
AuthorsS Fodré, K Sipos, G Berencsi
JournalZentralblatt fur Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene. Erste Abteilung Originale. Reihe B: Hygiene, Betriebshygiene, praventive Medizin (Zentralbl Bakteriol B) Vol. 169 Issue 5-6 Pg. 482-7 ( 1979) Germany
Vernacular TitleDie Bedeutung der immunologischen Konstellation bei der Entwicklung einer Uberempfindlichkeit gegen verschiedene Chemikalien.
PMID545948 (Publication Type: Comparative Study, English Abstract, Journal Article)
Chemical References
  • Adjuvants, Immunologic
  • BCG Vaccine
  • Detergents
  • Haptens
  • Immune Sera
  • Organic Chemicals
  • Tuberculin
  • Biopon
Topics
  • Adjuvants, Immunologic
  • Animals
  • BCG Vaccine (immunology)
  • Detergents (immunology)
  • Drug Hypersensitivity (immunology)
  • Guinea Pigs
  • Haptens
  • Immune Sera (immunology)
  • Male
  • Organic Chemicals
  • Tuberculin (immunology)

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