Effect of trimethoprim-sulphamethoxazole on typhoid and salmonella carriers.

Abstract

Four chronic typhoid carriers from the Aberdeen typhoid outbreak of 1964 were treated with trimethoprim-sulphamethoxazole. The male carrier remained clear of infection following treatment but the three female carriers, all with gall bladder abnormalities, remained excretors. A convalescent typhoid excretor also remained clear of infection after treatment as well as two other salmonella carriers, one of whom has been a chronic carrier for 24 years.

• Authors: J Brodie, I A Macqueen, D Livingstone
• Journal: British medical journal (Br Med J) Vol. 3 Issue 5718 Pg. 318-9 (Aug 08 1970) ISSN: 0007-1447 [Print] England
• PMID: 5451954 (Publication Type: Journal Article)

Chemical References

• Folic Acid Antagonists
• Pyrimidines
• Sulfamethoxazole

Topics

• Adult
• Aged
• Carrier State (drug therapy)
• Feces (microbiology)
• Female
• Folic Acid Antagonists (therapeutic use)
• Gallbladder Diseases (complications)
• Humans
• Male
• Middle Aged
• Pyrimidines (therapeutic use)
• Salmonella Infections
• Salmonella typhi (isolation & purification)
• Sulfamethoxazole (therapeutic use)
• Typhoid Fever
• Urine (microbiology)