Lung carcinoma induction in BD rats after a single intratracheal instillation of an arsenic-containing pesticide mixture formerly used in vineyards.

Abstract	A single intratracheal 0.1-ml instillation of a calcium-arsenate containing vineyard pesticide induced multi-focal bronchogenic adenocarcinomas and bronchiolar-alveolar-cell carcinomas in nine out of 15 treated BD rats. This seems to be the first experimental confirmation of carcinogenicity of arsenic-containing pesticides used formerly in vineyards.
Authors	S Ivankovic, G Eisenbrand, R Preussmann
Journal	International journal of cancer (Int J Cancer) Vol. 24 Issue 6 Pg. 786-8 (Dec 15 1979) ISSN: 0020-7136 [Print] United States
PMID	544532 (Publication Type: Comparative Study, Journal Article)
Chemical References	Arsenates Pesticides Arsenic
Topics	Adenocarcinoma (chemically induced) Animals Arsenates (adverse effects) Arsenic (adverse effects) Carcinoma, Bronchogenic (chemically induced) Fruit Injections Lung (drug effects, pathology) Lung Neoplasms (chemically induced) Male Neoplasms, Experimental (chemically induced) Pesticides (adverse effects) Rats Trachea

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