Cytocidal effect of rifamycin derivatives on ascites tumor cells: studies with [125I]iododeoxyuridine.

Abstract

The cytotoxicity of 2 rifamycin derivatives, rifazone-82 and rifampicin, on mouse ascites cells was studied, using the [125I]iododeoxyuridine (IUDR) method of labeling the tumor cells. This technique allows a distinction to be made between a cytocidal and cytostatic effect. The 2 drugs exerted a cytocidal effect against 2 non-leukemic cell lines, but had no effect against 3 leukemic lines.

• Authors: A M Hughes, M Calvin
• Journal: Cancer letters (Cancer Lett) Vol. 6 Issue 1 Pg. 15-9 (Jan 1979) ISSN: 0304-3835 [Print] Ireland
• PMID: 544007 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)

Chemical References

• Iodine Radioisotopes
• Rifamycins
• rifazone-82
• Idoxuridine
• Rifampin

Topics

• Adenocarcinoma (drug therapy)
• Animals
• Carcinoma, Ehrlich Tumor (drug therapy)
• Cell Line
• Cell Survival (drug effects)
• Female
• Idoxuridine (metabolism)
• Iodine Radioisotopes
• Leukemia, Experimental (drug therapy)
• Mice
• Neoplasm Transplantation
• Neoplasms, Experimental (drug therapy)
• Rifampin (therapeutic use)
• Rifamycins (therapeutic use)
• Transplantation, Homologous