Abstract |
In 13 newborns and 12 prematures the pharmacokinetic parameters of 6-[(R)-2-(2-oxo- imidazolidine-1-carboxamido)-2-phenyl-acetamido]- penicillanic acid sodium salt ( azlocillin, Securopen), were investigated after a single i.v. load of 50 mg/kg body weight. From the concentration-time curve an open two-compartment model could be postulated. The values of the microconstants indicate that there is a rapid diffusion from the peripheral compartment into the central one. The elimination half-life calculated from the beta-slope is 2.6-2.5 h. differences between newborns and prematures are lacking. To reach an average steady-state concentration C-infinity between 50 and 80 microgram/ml plasma, 100-200 mg azlocillin/kg body weight during 24h must be given. The accumulation rates for a dosage interval of 6 or 8 h are 0.6 and 0.45.
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Authors | G Heimann, B von Heereman, E Gladtke |
Journal | Arzneimittel-Forschung
(Arzneimittelforschung)
Vol. 29
Issue 12a
Pg. 1949-51
( 1979)
ISSN: 0004-4172 [Print] Germany |
Vernacular Title | Pharmakokinetik von Azlocillin bei Früh- und Neugeborenen. |
PMID | 543897
(Publication Type: English Abstract, Journal Article)
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Chemical References |
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Topics |
- Azlocillin
- Half-Life
- Humans
- Infant, Newborn
- Infant, Premature
- Models, Biological
- Penicillins
(metabolism)
- Time Factors
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