[On the influence of clanobutine on the formation of restraint ulcer in rats (author's transl)].

Abstract

Prophylactic effect of 4-[(4-chlorobenzoyl)(4-methoxyphenyl)-amino]-butyric acid (clanobutine, Bykahepar) on restraint stress ulcer formation was studied in male albino rats. Number and size of ulcers were counted, pH value of gastric juice and plasma levels of corticoids, glucagon and blood sugar were measured. Rats treated with clanobutine had only the one-third of ulcers compared with the untreated animals. This effect was found to be dose-dependent. Clanobutine did not change plasma levels of corticoids, glucagon or blood sugar. Rise in pH value of gastric juice during stress exposition was found to be lower in clanobutine treated animals than in untreated controls. Blood flow in gastrointestinal tract was seen to be much better under the influence of clanobutine. The mechanism of action of clanobutine is discussed.

• Authors: K Hengst, T Hossdorf, H Wagner, U Gerlach
• Journal: Arzneimittel-Forschung (Arzneimittelforschung) Vol. 29 Issue 11 Pg. 1701-4 ( 1979) ISSN: 0004-4172 [Print] Germany
• Vernacular Title: Zur Wirkung von Clanobutin auf die Ulkus-Entstehung bei der Ratte im Immobilisationsstress.
• PMID: 543879 (Publication Type: English Abstract, Journal Article)

Chemical References

• Anti-Ulcer Agents
• Benzamides
• gamma-Aminobutyric Acid
• clanobutin

Topics

• Animals
• Anti-Ulcer Agents (therapeutic use)
• Benzamides (therapeutic use)
• Male
• Rats
• Restraint, Physical
• Stomach Ulcer (prevention & control)
• gamma-Aminobutyric Acid (analogs & derivatives, therapeutic use)