Abstract |
Thiols are the most reactive nucleophilic reagents among the biological models investigated. They undergo "Michael-type" addition to the polyfunctional sesquiterpene lactones. The rapid rates of reaction with L-cysteine were measured and the reaction products were characterized. Each addition of thiol successively decreased the cytotoxicity of the adducts formed.
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Authors | S M Kupchan, D C Fessler, M A Eakin, T J Giacobbe |
Journal | Science (New York, N.Y.)
(Science)
Vol. 168
Issue 3929
Pg. 376-8
(Apr 17 1970)
ISSN: 0036-8075 [Print] United States |
PMID | 5435896
(Publication Type: Journal Article)
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Chemical References |
- Antineoplastic Agents
- Lactones
- Plant Growth Regulators
- Terpenes
- Cysteine
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Topics |
- Antineoplastic Agents
(pharmacology)
- Chemistry, Pharmaceutical
- Chromatography, Thin Layer
- Cysteine
- Lactones
- Plant Growth Regulators
- Spectrophotometry
- Terpenes
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