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Reactions of alpha methylene lactone tumor inhibitors with model biological nucelophiles.

Abstract
Thiols are the most reactive nucleophilic reagents among the biological models investigated. They undergo "Michael-type" addition to the polyfunctional sesquiterpene lactones. The rapid rates of reaction with L-cysteine were measured and the reaction products were characterized. Each addition of thiol successively decreased the cytotoxicity of the adducts formed.
AuthorsS M Kupchan, D C Fessler, M A Eakin, T J Giacobbe
JournalScience (New York, N.Y.) (Science) Vol. 168 Issue 3929 Pg. 376-8 (Apr 17 1970) ISSN: 0036-8075 [Print] United States
PMID5435896 (Publication Type: Journal Article)
Chemical References
  • Antineoplastic Agents
  • Lactones
  • Plant Growth Regulators
  • Terpenes
  • Cysteine
Topics
  • Antineoplastic Agents (pharmacology)
  • Chemistry, Pharmaceutical
  • Chromatography, Thin Layer
  • Cysteine
  • Lactones
  • Plant Growth Regulators
  • Spectrophotometry
  • Terpenes

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