HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Coagulation problems relating to vitamin E.

Abstract
In the studies outlined in this report, normal dogs receiving megadoses of vitamin E displayed no abnormalities in their coagulation mechanisms. However, when made mildly vitamin-K-deficient by using warfarin, the introduction of vitamin E produced a profound coagulopathy. This coagulopathy was characterized by a further reduction in the vitamin-K-dependent coagulation factors and did not influence the levels of the non-vitamin K coagulation factors. Only one human case has been described to date, and this particular patients was vitamin-K-deficient at the time he was receiving vitamin E. Further studies are necessary to ascertain the usefulness of this vitamin in trombotic disease and to define the possible hematological toxicity in those patients with concomitant vitamin K deficiency.
AuthorsJ J Corrigan Jr
JournalThe American journal of pediatric hematology/oncology (Am J Pediatr Hematol Oncol) Vol. 1 Issue 2 Pg. 169-73 ( 1979) ISSN: 0192-8562 [Print] United States
PMID543511 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Vitamin E
  • Warfarin
Topics
  • Animals
  • Blood Coagulation (drug effects)
  • Dogs
  • Dose-Response Relationship, Drug
  • Humans
  • Injections, Intravenous
  • Middle Aged
  • Vitamin E (pharmacology)
  • Vitamin K Deficiency (chemically induced)
  • Warfarin (pharmacology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: