[E-vitamin activity of vitamin E derivatives with experimental encephalomalacia in chicks].

When adding pharmacopoeian alpha-tocopherylacetate, short-chain alpha-tocopherylacetate, alpha-tocopherylquinine, short-chain alpha-tocopherylquinone and alpha-tocopheronolactone to E-avitaminotic rations pharmacopoeian alpha-tocopherylacetate and alpha-tocopheronolactone manifest the highest E-vitamin activity in preventing encephalomalacia in chickens. The action of alpha-tocopheronolactone is not directly associated with changes in the content of vitamin E and ubiquinone in the brain and liver tissues. All the studied derivatives are effective in increasing resistance of erythrocytes to osmotic hemolysis. The data obtained evidence for a nonspecific function of vitamin E in preventing alimentary encephalomalacia in chickens as well as for the absence of disturbances in ubiquinone metabolism under conditions of the E-hypovitaminosis experimental model.
AuthorsV N Kovalenko, G V Donchenko, V P Makovetskiĭ, A A Svishchuk
JournalUkrainskiĭ biokhimicheskiĭ zhurnal (1978) (Ukr Biokhim Zh (1978)) 1979 Nov-Dec Vol. 51 Issue 6 Pg. 665-8 ISSN: 0201-8470 [Print] USSR
Vernacular TitleE-vitaminnaia aktivnost' proizvodnykh vitamina E pri eksperimental'noĭ entsefalomaliatsii u tsypliat.
PMID543031 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Vitamin E
  • Animals
  • Chickens
  • Disease Models, Animal
  • Encephalomalacia (drug therapy)
  • Structure-Activity Relationship
  • Vitamin E (analogs & derivatives, therapeutic use)

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