| Abstract | Intravenous doses of amantadine hydrochloride, an antiviral drug, as small as 0.08 milligram per kilogram may release dopamine and other catecholamines from neuronal storage sites in dogs primed with dopamine. This release may account for the reported efficacy of amantadine hydrochloride in the treatment of human parkinsonism. |
| Authors | R P Grelak, R Clark, J M Stump, V G Vernier |
| Journal | Science (New York, N.Y.)
(Science)
Vol. 169
Issue 941
Pg. 203-4
(Jul 10 1970)
ISSN: 0036-8075 UNITED STATES |
| PMID | 5427356
(Publication Type: Journal Article)
|
| Chemical References |
- Atropine
- Dopamine
- Acetylcholine
- Amantadine
|
| Topics |
- Acetylcholine
(antagonists & inhibitors)
- Amantadine
(pharmacology, therapeutic use)
- Animals
- Atropine
(pharmacology)
- Dogs
- Dopamine
(pharmacology, secretion)
- Neurons
(secretion)
- Parkinson Disease
(drug therapy, physiopathology)
- Stimulation, Chemical
- Vagotomy
|
