The alkaloids of Delphinium cashmirianum.

Abstract

Dephinium cashmirianum Royle (Ranunculaceae) has yielded the new base cashmiradelphine (12), together with the known alkaloids anthranoyllycoctonine (9), lycaconitine (15), avadharidine (17), lappaconitine (4), and N-deacetyllappaconitine (7). Pyridinium chlorochromate oxidation of lycoctonine furnished the new aldehyde lycoctonal (11). The arrhythmogenic and heart rate effects of several of these diterpenoidal alkaloids have been measured on the isolated guinea atria. Lappaconitine was arrhythmogenic at 10(-4)M concentrations. But in contrast to the reference drug aconitine, lappaconitine did not increase the heart rate. In anesthetized rabbits injected with lappaconitine, N-deacetyllappaconitine, and lappaconine up to 1 mg/kg, cardiac arrhythmia was quickly observed. Even up to 5 mg/kg, the other substances were non-arrhythmogenic.

• Authors: M Shamma, P Chinnasamy, G A Miana, A Khan, M Bashir, M Salazar, P Patil, J L Beal
• Journal: Journal of natural products (J Nat Prod) 1979 Nov-Dec Vol. 42 Issue 6 Pg. 615-23 ISSN: 0163-3864 [Print] United States
• PMID: 541686 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Alkaloids

Topics

• Alkaloids (isolation & purification, pharmacology)
• Animals
• Arrhythmias, Cardiac (chemically induced)
• Blood Pressure (drug effects)
• Dose-Response Relationship, Drug
• Female
• Guinea Pigs
• Heart Rate (drug effects)
• In Vitro Techniques
• Male
• Plants (analysis)
• Rabbits