Cerebrocortical necrosis in ruminants: effect of thiaminase type 1-producing Clostridium sporogenes in lambs.

Abstract

Large numbers of orally inoculated thiaminase type 1-producing Clostridium sporogenes failed to establish in the alimentary tract of two conventionally born lambs. Conversely, when similar inoculations were given to two gnotobiotic lambs, large populations of Cl sporogenes established in their rumens and correspondingly high levels of thiaminase were produced. No clinical symptoms of thiamine deficiency or cerebrocortical necrosis were seen despite the presence of high levels of thiaminase in the rumen of one of the gnotobiotic lambs for a period of 86 days.

• Authors: G H Cushnie, A J Richardson, W J Lawson, G A Sharman
• Journal: The Veterinary record (Vet Rec) Vol. 105 Issue 21 Pg. 480-2 (Nov 24 1979) ISSN: 0042-4900 [Print] England
• PMID: 538876 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Transferases
• Alkyl and Aryl Transferases
• thiamin pyridinylase

Topics

• Alkyl and Aryl Transferases
• Animals
• Clostridium (enzymology)
• Encephalomalacia (etiology, veterinary)
• Feces (enzymology, microbiology)
• Germ-Free Life
• Rumen (enzymology, microbiology)
• Sheep
• Sheep Diseases (etiology)
• Thiamine Deficiency (etiology, veterinary)
• Transferases (metabolism)