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Genetic influence on the development of renoprival hypertension in parabiotic rats. Evidence that a humoral hypertensinogenic factor is produced in kidney tissue of hypertension-prone rats.

Abstract
Rats from two strains with opposite constitutional predisposition to hypertension were joined in parabiosis and one partner was nephrectomized. The influence of genetic factors and of diet on the blood pressures of the two classes of parabionts, operated and intact, indicated that renoprival hypertension occurred with equal frequency in rats from both strains; that the development of renoprival hypertension depended on the influence from an intact S partner, or on a high salt intake, or on both. A nephrectomized S rat developing renoprival hypertension did not induce high blood pressure in its intact R partner. In this respect renoprival hypertension differs from salt and renal hypertension. The findings are interpreted to mean that the hypertensinogenic agent specific for S rats is produced by S kidneys.
AuthorsK D Knudsen, J Iwai, M Heine, G Leitl, L K Dahl
JournalThe Journal of experimental medicine (J Exp Med) Vol. 130 Issue 6 Pg. 1353-65 (Dec 01 1969) ISSN: 0022-1007 [Print] United States
PMID5352784 (Publication Type: Journal Article)
Chemical References
  • Sodium Chloride
Topics
  • Analysis of Variance
  • Animals
  • Blood Pressure (drug effects)
  • Diet, Sodium-Restricted
  • Genetics
  • Hypertension, Renal (genetics)
  • Kidney (physiology)
  • Methods
  • Nephrectomy
  • Parabiosis
  • Sodium Chloride (pharmacology)
  • Species Specificity

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