tcPO2 in pediatric cardiology: application during balloon septostomy, tolazoline administration, and in children with right-to-left shunt.

Abstract

In pediatric cardiology tcPO2 is useful in monitoring cyanotic children given high-risk therapy such as balloon septostomy or drugs with controversial effects such as tolazoline in persistent fetal circulation. tcPO2 during administration of 100% oxygen enables a rapid, noninvasive differentiation between cyanosis due to intracardiac right-to-left shunt and that due to low cardiac output or pulmonary ventilation or diffusion difficulty. The size of the right-to-left shunt can be roughly estimated from the highest value of tcPO2, this estimation being influenced by anemia, hypothermia, and acidosis, among other factors. A trend of the tcPO2 rise is evident 90 seconds after the beginning of oxygen breathing. If tcPO2 does not rise at least 40 mm Hg over the initial value, a significant right-to-left shunt must be suspected. Interpretation of tcPO2 rise is difficult in dynamic right-to-left shunt, changing with oxygen breathing.

• Authors: H U Bucher, U Arbenz, A Bucher
• Journal: Birth defects original article series (Birth Defects Orig Artic Ser) Vol. 15 Issue 4 Pg. 355-63 ( 1979) ISSN: 0547-6844 [Print] United States
• PMID: 534716 (Publication Type: Journal Article)

Chemical References

• Tolazoline
• Oxygen

Topics

• Blood Gas Analysis
• Cardiac Catheterization
• Cyanosis (diagnosis, physiopathology)
• Female
• Heart Septal Defects (diagnosis, physiopathology)
• Humans
• Infant, Newborn
• Infant, Newborn, Diseases (diagnosis, physiopathology)
• Male
• Oxygen (blood)
• Partial Pressure
• Persistent Fetal Circulation Syndrome (diagnosis, physiopathology)
• Respiration
• Skin (blood supply)
• Tolazoline (therapeutic use)