Cerebrospinal fluid immunoglobulins in children.

Abstract

Cerebrospinal fluid (CSF) immunoglobulins were measured in 62 normal children, in 9 children with purulent meningitis, and in 10 children with presumptive viral meningitis. The mean values in normal children were IgA 0, IgM 0, and IgG 0.84 +/- 1.4 mg/100 ml (+/- SD). The mean levels of all CSF immunoglobulins were raised in acute bacterial meningitis and were significantly greater than the levels found in viral meningitis. CSF IgM was 0.16 +/- 0.5 mg/100 ml in viral meningitis compared with 2.64 +/- 2.06 mg/100 ml in bacterial meningitis (P less than 0.01). However, these values overlapped to a considerable extent and, generally, measurement of CSF immunoglobulins did not enhance diagnostic accuracy in this group of children.

• Authors: D G Gill, M Brody
• Journal: Archives of disease in childhood (Arch Dis Child) Vol. 54 Issue 12 Pg. 961-2 (Dec 1979) ISSN: 1468-2044 [Electronic] England
• PMID: 533301 (Publication Type: Journal Article)

Chemical References

• Cerebrospinal Fluid Proteins
• Immunoglobulin A
• Immunoglobulin G
• Immunoglobulin M
• Immunoglobulins

Topics

• Cerebrospinal Fluid Proteins (analysis)
• Child
• Child, Preschool
• Humans
• Immunoglobulin A (cerebrospinal fluid)
• Immunoglobulin G (cerebrospinal fluid)
• Immunoglobulin M (cerebrospinal fluid)
• Immunoglobulins (cerebrospinal fluid)
• Infant
• Meningitis (cerebrospinal fluid, immunology)
• Meningitis, Viral (cerebrospinal fluid, immunology)