HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

[Relation between ceruloplasmin and vitamin A in Sprague-Dawley rats].

Abstract
The Moore's hypothesis concerning a relationship between the metabolism of copper and that of vitamin A led us to consider a possible relationship between this vitamin and ceruloplasmin, the carrier protein for copper. Experiments were carried out on Sprague-Dawley rats. The ceruloplasmin level of control animals and vitamin A - deficient rats was determined An average increase between 22 and 33% was observed in the animals with vitamin A deficiency, the highest levels being observed in the females. These results are in agreement with Peterson's previous work. A second type of experiment was carried out to confirm these results. The rats were raised in a copper-deficient diet and the vitamin A level was regularly determined. In these conditions serum and liver levels of vitamin A are normal and do not vary, ceruloplasmin level is zero; however apoceruloplasmin is still being synthetized : Nevertheless at the ultime state of the deficiency vitamin A level decreases while apoceruloplasmin increases. These results raise the following question. Could the relationship between ceruloplasmin and vitamin A be possibly due to an inflammatory state in vitamin A deficient rats. In this respect a third series of experiments were undertaken and are in progress; the vitamin A and ceruloplasmin levels are regularly determined.
AuthorsL Cloarec, M R Durou, B Legras, J Y Esvant
JournalAnnales de la nutrition et de l'alimentation (Ann Nutr Aliment) Vol. 33 Issue 3 Pg. 385-93 ( 1979) ISSN: 0003-4037 [Print] France
Vernacular TitleRelation entre céruloplasmine et vitamine A chez le rat de souche Sprague-Dawley.
PMID533078 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Vitamin A
  • Copper
  • Ceruloplasmin
Topics
  • Animals
  • Body Weight
  • Ceruloplasmin (metabolism)
  • Copper (deficiency)
  • Female
  • Male
  • Rats
  • Vitamin A (blood, metabolism)
  • Vitamin A Deficiency (metabolism)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: