Effect of psychotropic drugs on the development of experimental gastric ulcer produced by different stress-inducing factors in rats.

Abstract

The anti-ulcer activity of three different doses (1/10, 1/30 and 1/90 of LD50) of imipramine, amitryptyline, chlorpromazine, amphetamine, ephedrine, chlordiazepoxide and meprobamate was studied in two types of stress-produced gastric ulcers in rats. It was found that these drugs given in doses of 1/10 or 1/30 LD50 inhibited in the same degree the development of gastric ulcer-produced by the method of Senay, in spite of differences in their psychotropic activity. On the other hand, when the method of Rossi was used for ulcer production the ulcer-preventing activity of these drugs has been varied. Thymoleptics were most effective and ataractics least effective against ulcers produced by the method of Rossi.

• Authors: I Małecki, B Borkowska, I Wegrzyn
• Journal: Acta physiologica Polonica (Acta Physiol Pol) 1979 Sep-Dec Vol. 30 Issue 5-6 Pg. 649-56 ISSN: 0044-6033 [Print] Poland
• PMID: 532676 (Publication Type: Journal Article)

Chemical References

• Psychotropic Drugs
• Amitriptyline
• Chlordiazepoxide
• Meprobamate
• Amphetamine
• Ephedrine
• Imipramine
• Chlorpromazine

Topics

• Amitriptyline (therapeutic use)
• Amphetamine (therapeutic use)
• Animals
• Chlordiazepoxide (therapeutic use)
• Chlorpromazine (therapeutic use)
• Ephedrine (therapeutic use)
• Imipramine (therapeutic use)
• Immobilization
• Male
• Meprobamate (therapeutic use)
• Psychotropic Drugs (therapeutic use)
• Rats
• Stomach Ulcer (etiology, prevention & control)
• Stress, Physiological (complications)