Studies of calcitonin cells and parathyroid gland of house shrew, Suncus murinus in response to experimental hypercalcemia.

1. Hypercalcemia was induced in S. murinus by alternate day intramuscular injections of vitamin D (25 000 IU) and by providing them 1% CaCl2 solution (prepared in tap water) for drinking. 2. After such a treatment the serum calcium values recorded a rise as compared to those of the control specimens. 3. The histological picture of the thyroid of the treated specimens reveals increased number of calcitonin cells. This observation is supported by the occurrence of mitotic figures among them. 4. Perpetual calcium challenge results in degranulation of the secretory material (calcitonin) among these cells (at 26th and 30th day of treatment). 5. It also results in degenerative changes in certain number of C cells. 6. The blood capillaries around these cells get dilated and secretory granules of C cells tend to gather at the periphery of cytoplasm and towards vascular pole. 7. The parathyroid shows atrophic changes.
AuthorsK Swarup, A K Srivastav
JournalZeitschrift für mikroskopisch-anatomische Forschung (Z Mikrosk Anat Forsch) Vol. 93 Issue 2 Pg. 343-52 ( 1979) ISSN: 0044-3107 [Print] GERMANY, EAST
PMID532267 (Publication Type: Journal Article)
Chemical References
  • Vitamin D
  • Calcitonin
  • Calcium Chloride
  • Animals
  • Calcitonin (secretion)
  • Calcium Chloride
  • Cell Nucleus (ultrastructure)
  • Cytoplasm (ultrastructure)
  • Cytoplasmic Granules (ultrastructure)
  • Female
  • Hypercalcemia (chemically induced, pathology)
  • Male
  • Parathyroid Glands (pathology)
  • Shrews (anatomy & histology)
  • Thyroid Gland (pathology)
  • Vitamin D

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: