The metabolism of isamoxole in the rat and guinea-pig.

Abstract

1. The absorption, metabolism and excretion of isamoxole, (2-methyl-N-butyl-N-(4-methyloxazol-2-yl)propanamide), a compound with anti-allergy properties, has been studied in the rat and guinea-pig. 2. The compound was well-absorbed by both species after oral doses of 50 to 150 mg/kg. It underwent extensive first-pass metabolism in the liver, and was excreted as a mixture of metabolites, predominantly in the urine, within 48 h. 3. Three major routes of metabolism were involved, namely deacylation, oxidative ring scission and alkyl oxidation. 4. A major plasma and urine metabolite was 1-butyl-3-(1-carboxyethyl)urea, and this was accompanied by low levels of its cyclized product 3-butyl-5-methylhydantoin.

• Authors: D H Chatfield, J N Green, J C Kao, W J Ross, T J Woodage
• Journal: Xenobiotica; the fate of foreign compounds in biological systems (Xenobiotica) Vol. 9 Issue 10 Pg. 585-94 (Oct 1979) ISSN: 0049-8254 [Print] England
• PMID: 532211 (Publication Type: Journal Article)

Chemical References

• Oxazoles
• isamoxole

Topics

• Animals
• Biotransformation
• Guinea Pigs
• Hypersensitivity (drug therapy)
• Intestinal Absorption
• Lung (metabolism)
• Male
• Oxazoles (blood, metabolism, urine)
• Rats
• Species Specificity