Abstract |
Male albino rats given a bilateral injection of Baclofen ( Lioresal) (12 micrograms/rat) in the cerebral ventricles showed a behavioral syndrome of activation + ataxia, paddling, tail-pinch hyperresponse and anesthesia. The phase of activation + ataxia was reduced by pretreatment of rats with H 44/68, FLA 63, reserpine, pimozide, phenoxybenzamine, oxypertine or chlorpromazine. The phase of paddling was reduced by pretreatment with FLA 63, reserpine, phenoxybenzamine, oxypertine, chlorpromazine, pimozide + phenoxybenzamine or apomorphine, while administration of clonidine instead of Baclofen caused paddling in non-pretreated rats. The phase of tail-pinch hyperresponse was reduced by reserpine, oxypertine, chlorpromazine or pimozide + phenoxybenzamine, while none of the pretreatments affected Baclofen-induced anesthesia. Drugs which affect mainly tryptaminergic or GABA-ergic functions failed to affect Baclofen-induced behaviors consistently. The findings suggest that dopaminergic and noradrenergic functions play a role in the central effects of Baclofen on behavior of rats.
|
Authors | D F Smith, P Vestergaard |
Journal | Journal of neural transmission
(J Neural Transm)
Vol. 46
Issue 3
Pg. 215-23
( 1979)
Austria |
PMID | 528996
(Publication Type: Journal Article)
|
Chemical References |
- Catecholamines
- Baclofen
- Clonidine
- Dopamine
- Norepinephrine
|
Topics |
- Anesthesia
- Animals
- Ataxia
(chemically induced)
- Baclofen
(administration & dosage, pharmacology)
- Catecholamines
(physiology)
- Clonidine
(pharmacology)
- Dopamine
(physiology)
- Injections, Intraventricular
- Male
- Motor Activity
(drug effects)
- Norepinephrine
(physiology)
- Rats
|