Synthesis and antibacterial activity of 1-N-(1,3-dihydroxy-2-propyl)kanamycin B (UK-31,214).

Abstract	1-N-(1,3-Dihydroxy-2-propyl)kanamycin B was prepared and its in vitro activity against aminoglycoside-sensitive and aminoglycoside-resistant organisms was compared with that of kanamycin B and gentamicin. This kanamycin B derivative (code No. UK-31,214) demonstrated potent activity in all of these tests and gave good protection in experimental infections in mice.
Authors	K Richardson, K W Brammer, S Jevons, R M Plews, J R Wright
Journal	The Journal of antibiotics (J Antibiot (Tokyo)) Vol. 32 Issue 10 Pg. 973-7 (Oct 1979) ISSN: 0021-8820 [Print] England
PMID	528375 (Publication Type: Journal Article)
Chemical References	Aminoglycosides Kanamycin 1-N-(1,3-dihydroxy-2-propyl)kanamycin B
Topics	Aminoglycosides (pharmacology) Animals Bacteria (drug effects) Bacterial Infections (drug therapy, microbiology) Drug Resistance, Microbial Female Kanamycin (analogs & derivatives, chemical synthesis, pharmacology) Mice Microbial Sensitivity Tests

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