[Antiprolactin therapy in the treatment of benign lesions of the breast. Comparison of bromocryptine and methergoline].

Abstract

The Authors have treated 11 patients with benign breast diseases (fibroadenosis or fibrocystic disease) with two prolactin inhibitor drugs -- metergoline and bromocriptine -- at the dose of 8 mg/die and 7,5 mg/die respectively for sixty days with a 30 days interval from one to the other. All patients, except one, had normal serum prolactin levels before the trial; during the treatment with metergoline no long-term changes in serum prolactin levels were observed; on the contrary, bromocriptine reduced significantly prolactin values for the whole duration of the therapy. Negative clinical results were obtained with the first drug, while bromocriptine allowed to reach an 80% of positive results at the end of the trial. Coming from previous experience, the Authors conclude that the positive therapeutic effect of bromocriptine treatment is connected with the maintenance of prolactin reduction.

• Authors: A Mussa, S Sandrucci, L Dogliotti
• Journal: Minerva medica (Minerva Med) Vol. 70 Issue 51 Pg. 3493-8 (Nov 17 1979) ISSN: 0026-4806 [Print] Italy
• Vernacular Title: La terapia antiprolattinica nel trattamento delle lesioni benigne della mammella. Confronto tra bromocriptina e metergolina.
• PMID: 522987 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Ergolines
• Metergoline
• Bromocriptine
• Prolactin

Topics

• Adult
• Breast Diseases (drug therapy)
• Bromocriptine (therapeutic use)
• Ergolines (therapeutic use)
• Female
• Fibrocystic Breast Disease (drug therapy)
• Humans
• Metergoline (therapeutic use)
• Middle Aged
• Prolactin (antagonists & inhibitors, blood)