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In vitro biosynthesis of 18-hydroxy-11-deoxycorticosterone from deoxycorticosterone by human adrenal glands removed from patients with hypercorticism.

Abstract
The biosynthesis of 18-hydroxy-11-deoxycorticosterone (18-OH-DOC) was studied by in vitro incubations of human adrenals resected from patients with Cushing's syndrome, using deoxycorticosterone as precursor. 18-OH-DOC synthesis was similar in adrenals from normal subjects and in those derived from patients with different types of Cushing's syndrome (hyperplasia, adenoma, carcinoma). The in vitro addition of o,p'-DDD (5 x 10(-3) M) to an adrenocortical carcinoma incubation did not alter 18-OH-DOC biosynthesis. By contrast, treatment of the patient with o,p'-DDD prior to adrenalectomy resulted in a low production of 18-OH-DOC in vitro but only when cortisol synthesis was drastically decreased.
AuthorsY Touitou, A Bogdan, J P Luton
JournalClinical endocrinology (Clin Endocrinol (Oxf)) Vol. 11 Issue 1 Pg. 39-45 (Jul 1979) ISSN: 0300-0664 [Print] England
PMID519871 (Publication Type: Journal Article)
Chemical References
  • 18-Hydroxydesoxycorticosterone
  • Desoxycorticosterone
Topics
  • 18-Hydroxydesoxycorticosterone (metabolism)
  • Adrenal Gland Neoplasms (metabolism)
  • Adrenal Glands (metabolism)
  • Adrenalectomy
  • Adrenocortical Hyperfunction (metabolism, surgery)
  • Animals
  • Desoxycorticosterone (analogs & derivatives, metabolism)
  • Female
  • Humans
  • Rats

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