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Early biochemical liver changes following thiobenzamide poisoning.

Abstract
Administration of thiobenzamide in a single dose (25 mg/100 g body wt by stomach tube) to male rats induced centrilobular necrosis, which became evident 10 h after the poisoning. In the meantime liver weight and water content underwent changes, glycogen was lost, triglycerides accumulated in the liver while decreasing in serum, [3H] leucine uptake in proteins was impaired and the activity of glucose-6-phosphatase and aminopyrine demethylase decreased. The activity of NADPH-cytochrome c reductase remained unchanged, whereas a reduction of the microsomal cytochrome P-450 occurred. The liver amount of reduced glutathione underwent no significant changes. Pretreatment of the animals with cobalt chloride or 20-methylcholanthrene decreased the liver damage caused by the drug. The in vitro addition of thiobenzamide to liver microsomes resulted in a spectral change. The appearance of conjugated dienes among microsomal lipids from drug-treated rats indicated for a lipoperoxidation taking place in vivo.
AuthorsE Chieli, G Malvaldi, R Tongiani
JournalToxicology (Toxicology) 1979 Jun-Jul Vol. 13 Issue 2 Pg. 101-14 ISSN: 0300-483X [Print] Ireland
PMID516072 (Publication Type: Journal Article)
Chemical References
  • Benzamides
  • Thioamides
  • Thiones
  • thiobenzamide
  • Mixed Function Oxygenases
  • Alanine Transaminase
  • Leucine
Topics
  • Alanine Transaminase (metabolism)
  • Animals
  • Benzamides (poisoning)
  • Chemical and Drug Induced Liver Injury (etiology, metabolism, pathology)
  • Leucine (metabolism)
  • Lipid Metabolism
  • Liver (enzymology)
  • Male
  • Mixed Function Oxygenases (metabolism)
  • Necrosis
  • Organ Size (drug effects)
  • Rats
  • Thioamides
  • Thiones (poisoning)
  • Time Factors

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