Abstract |
The effect of McN-A-343 was studied by direct administration into the sinus node artery of dogs vagotomized at the mid-cervical level. McN-A-343 blocked sinus bradycardia caused by electrical stimulation of the right vagus, while bradycardia induced by administration of acetylcholine or nicotine into the sinus node artery was not modified.
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Authors | S Chiba, K Hashimoto, K Kubota, S Sato |
Journal | British journal of pharmacology
(Br J Pharmacol)
Vol. 43
Issue 3
Pg. 675-6
(Nov 1971)
ISSN: 0007-1188 [Print] England |
PMID | 5157729
(Publication Type: Journal Article)
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Chemical References |
- Carbamates
- Quaternary Ammonium Compounds
- Nicotine
- Acetylcholine
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Topics |
- Acetylcholine
(pharmacology)
- Animals
- Carbamates
(pharmacology)
- Dogs
- Electric Stimulation
- Heart Rate
(drug effects)
- Nicotine
(pharmacology)
- Quaternary Ammonium Compounds
(pharmacology)
- Sinoatrial Node
(drug effects)
- Vagotomy
- Vagus Nerve
(drug effects)
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