An intravenous preparation of
doxycycline (
DOTC,
Vibramycin 'Pfizer'), a long-lasting
tetracycline, was administered mainly by
drip infusion for a series of study in the pediatrics field, and the results were as follows: 1)
DOTC (100 mg) was dissolved in a 100 ml of
glucose solution and 2--3 mg/kg was administered intravenously. When the total infusion time was adjusted between one to two hours, the peak serum level of
DOTC was seen at the end of infusion in each case. The serum level in a two-hour infusion time, however, the serum level was delectable for a long period of time: the serum level after 10 hours was 0.82--1.23 micrograms/ml. Above results suggest that
DOTC intravenous should be given in a two-hour infusion twice a day for applicable
infections in the pediatrics field. 2) Urine excretion of
DOTC was about a half (50%) of the administered dosage. 3)
DOTC was given mostly at about 3--5 mg/kg per day (twice a day) infusion to 25 children with five
infections, viz. acute angina lacunaris, acute
bronchitis,
bronchopneumonia,
Mycoplasma pneumonia and acute
urinary tract infections. A clinical improvement seemed attributable to
DOTC was clearly observed in 23 out of 25 patients (92%). 4).
DOTC infusion was also effective for Mycoplasma
meningoencephalitis, severe
Mycoplasma pneumonia associated with
pleuritis,
bronchitis and
bronchopneumonia with a lot of Staphylococcus aureus identified in the sputum medium, acute
urinary tract infections caused by E. coli. 5) Before and ten days after
DOTC infusion, laboratory tests for liver and renal functions and blood were performed. No noticeable abnormalities were found except one case with transient GOT and GPT elevations. Above summary was presented at the 26th annual meeting of Japan Society of
Chemotherapy in June 1978.