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Uroporphyrinogen 3 cosynthetase activity in the fox squirrel (Sciurus niger).

Abstract
The activity of uroporphyrinogen III cosynthetase in hemolyzates and tissue extracts from fox squirrels is much less than in similar preparations from gray squirrels. Low activity of this enzyme explains the production of large amounts of uroporphyrin I by the fox squirrel. Members of this species thus provide a small-animal model for studies of congenital erythropoietic porphyria, a hereditary disease of man and cattle which is associated with a similar partial deficiency of uroporphyrinogen III cosynthetase.
AuthorsE Y Levin, V Flyger
JournalScience (New York, N.Y.) (Science) Vol. 174 Issue 4004 Pg. 59-60 (Oct 1 1971) ISSN: 0036-8075 [Print] UNITED STATES
PMID5120867 (Publication Type: Journal Article)
Chemical References
  • Hemoglobins
  • Porphyrins
  • Propionates
  • Pyrroles
  • Isomerases
Topics
  • Animals
  • Blood Cell Count
  • Disease Models, Animal
  • Hemoglobins (analysis)
  • Isomerases (analysis)
  • Kidney (enzymology)
  • Liver (enzymology)
  • Myocardium (enzymology)
  • Porphyrias
  • Porphyrins (biosynthesis)
  • Propionates
  • Pyrroles
  • Reticulocytes
  • Sciuridae (metabolism)
  • Spleen (enzymology)

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