Abstract |
The clinical diagnosis of Wolman's disease ( acid esterase deficiency) can be confirmed by a histochemical staining method using blood films. Acid esterase activity is found normally in lymphocytes, but in Wolman's disease only a very low level of activity can be detected. An intermediate level of activity was demonstrated in heterozygotes. The method may also be applicable in the prenatal detection of the disease.
|
Authors | B D Lake |
Journal | Journal of clinical pathology
(J Clin Pathol)
Vol. 24
Issue 7
Pg. 617-20
(Oct 1971)
ISSN: 0021-9746 [Print] England |
PMID | 5118828
(Publication Type: Journal Article)
|
Chemical References |
|
Topics |
- Esterases
(blood)
- Female
- Fetal Diseases
(diagnosis)
- Heterozygote
- Histocytochemistry
- Humans
- Lipidoses
(genetics)
- Lymphocytes
(enzymology)
- Male
- Membranes
- Microscopy, Electron
- Pregnancy
- Xanthomatosis
(enzymology, genetics)
|