HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Tumors of the rat kidney induced by nitrosourea compounds.

Abstract
Apart from other lesions, 51 renal neoplasms were induced in rats by administration of methylethy-, dimethyl- and phenylmethylnitrosourea. 3 tumors originated from the renal pelvis and were classified as transitional cell papilloma (1) or transitional cell carcinoma (2). 48 neoplasms were considered as "mesenchymal tumors". These growths were regarded as rat kidney specific tumors. They display a wide spectrum of histological structures: spindle cells which are capable to differentiate into smooth muscle cells, fibroblasts, angioblasts, fat cells, and even into cartilage thus forming the typical microscopical features which are completed by the tendency of mesenchymal cells to swirl around preexisting renal tubules in several closely investing layers. As the cell of origin is not yet established the term "mesenchymal tumor" seems to be the most suitable one. There is no basis for classifying these tumor as nephroblastomas and the two entities should be strictly separated.
AuthorsR Warzok, D Schreiber, E M Blaufuss
JournalExperimentelle Pathologie (Exp Pathol (Jena)) Vol. 17 Issue 7-8 Pg. 394-402 ( 1979) ISSN: 0014-4908 [Print] Germany
PMID510452 (Publication Type: Journal Article)
Chemical References
  • Nitrosourea Compounds
  • Methylnitrosourea
  • Ethylnitrosourea
Topics
  • Animals
  • Basement Membrane (pathology)
  • Epithelium (pathology)
  • Ethylnitrosourea (toxicity)
  • Female
  • Kidney (pathology)
  • Kidney Cortex (pathology)
  • Kidney Glomerulus (pathology)
  • Kidney Neoplasms (chemically induced, pathology)
  • Kidney Tubules (pathology)
  • Male
  • Methylnitrosourea (toxicity)
  • Nitrosourea Compounds (toxicity)
  • Rats

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: