Effects of styrene oxide on chromosome aberrations, sister chromatid exchange and hepatic drug biotransformation in chinese hamsters in vivo.

Abstract

In vivo inhalation exposure to styrene oxide (25, 50, 75 and 100 ppm) for 2, 4 or 20 days (25 ppm only) had no effects on chromosomal aberration rates or sister chromatid exchange (SCE) frequencies (BrdU/labelling performed in vitro) in the bone marrow cells of Chinese hamsters. The only positive response in aberration frequency was obtained when styrene oxide was injected in lethal concentration (500 mg/kg body weight, i.p.) into the animal. One animal out of six showed slightly elevated SCE values after this high dose. The response of the hepatic drug metabolizing enzymes to styrene oxide exposure was found to be rather weak, which may be due to rather high activity of epoxide hydratase in Chinese hamsters as compared to e.g. mouse.

• Authors: H Norppa, E Elovaara, K Husgafvel-Pursiainen, M Sorsa, H Vainio
• Journal: Chemico-biological interactions (Chem Biol Interact) Vol. 26 Issue 3 Pg. 305-15 (Aug 1979) ISSN: 0009-2797 [Print] Ireland
• PMID: 509693 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)

Chemical References

• Oxides
• Styrenes
• Cytochrome P-450 Enzyme System

Topics

• Animals
• Atmosphere Exposure Chambers
• Bone Marrow (drug effects)
• Bone Marrow Cells
• Chromatids (drug effects)
• Chromosome Aberrations
• Cricetinae
• Cricetulus
• Cytochrome P-450 Enzyme System (metabolism)
• Injections, Intraperitoneal
• Liver (drug effects, metabolism)
• Male
• Oxides (toxicity)
• Styrenes (toxicity)