Disseminated intravascular coagulation induced with leukocyte procoagulant.

Abstract

The procoagulant activity of rabbit peritoneal leukocytes significantly increased when the leukocytes were incubated in suspension cultures at 37 C for 24 hours. Intravenous infusions of Iysates of 232 x 10(6) rabbit leukocytes which had been incubated in cultures at 37 C for 24 hours produced disseminated intravascular coagulation and vasculitis involving the pulmonary arteries in normal rabbits. Intraaortic infusions of lysates of 230 x 10(6) similarly incubated leukocytes produced renal thrombosis and renal cortical necrosis in normal rabbits. These observations suggest that the procoagulant of granulocytic leukocytes could play a role in the generalized Shwartzman reaction and other syndromes of disseminated intravascular coagulation.

• Authors: G J Kociba, R A Griesemer
• Journal: The American journal of pathology (Am J Pathol) Vol. 69 Issue 3 Pg. 407-20 (Dec 1972) ISSN: 0002-9440 [Print] United States
• PMID: 5086898 (Publication Type: Journal Article)

Chemical References

• Blood Coagulation Factors

Topics

• Animals
• Blood Coagulation Factors (administration & dosage, metabolism)
• Disseminated Intravascular Coagulation (chemically induced, pathology)
• Injections, Intra-Arterial
• Injections, Intravenous
• Kidney Cortex Necrosis (chemically induced, pathology)
• Leukocytes (metabolism)
• Pulmonary Artery (pathology)
• Rabbits
• Renal Artery (pathology)
• Shwartzman Phenomenon (etiology)