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Response of the solid Guerin epitheliomas of rats to fractionated irradiation and a new 4-nitroimidazole.

Abstract
The transplantable Guerin epithelioma in Wistar rats was used to test the in vivo effectiveness of 1-(2-hydroxy-3-methoxypropyl)-2-methyl-4-nitroimidazole (P1) as a tumour-cell radiosensitizer after its oral administration at relatively low doses. The radiosensitizing ability of P1 was compared with that of metronidazole. The results indicate that P1 is less toxic than metronidazole, and greater concentrations of P1 in blood and tumour tissues are obtained for the same administered dose of the compounds. The radiosensitizing ability of P1, determined from tumour-regression rates and local-control percentage at 130 days, was higher than that of metronidazole.
AuthorsJ Watras, M Wideł, J Suwiński
JournalBritish journal of cancer (Br J Cancer) Vol. 40 Issue 3 Pg. 354-9 (Sep 1979) ISSN: 0007-0920 [Print] England
PMID508563 (Publication Type: Journal Article)
Chemical References
  • Nitroimidazoles
  • Metronidazole
Topics
  • Animals
  • Carcinoma, Squamous Cell (metabolism, radiotherapy)
  • Male
  • Metronidazole (metabolism, therapeutic use)
  • Neoplasm Transplantation
  • Neoplasms, Experimental (metabolism, radiotherapy)
  • Nitroimidazoles (metabolism, therapeutic use, toxicity)
  • Rats
  • Rats, Inbred Strains
  • Time Factors
  • Transplantation, Homologous

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