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Regulation of sterol biosynthesis and lysis of cultured hepatoma cells: inhibition of lanosterol demethylation by hydroxysterols.

AuthorsP R Ortiz de Montellano, J P Beck, G Ourisson
JournalBiochemical and biophysical research communications (Biochem Biophys Res Commun) Vol. 90 Issue 3 Pg. 897-903 (Oct 12 1979) ISSN: 0006-291X [Print] United States
PMID508352 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Hydroxycholesterols
  • Lanosterol
  • Desmosterol
  • Miconazole
  • Hydroxymethylglutaryl CoA Reductases
  • Mevalonic Acid
Topics
  • Animals
  • Cell Survival (drug effects)
  • Desmosterol (analogs & derivatives, pharmacology)
  • Hydroxycholesterols (pharmacology)
  • Hydroxymethylglutaryl CoA Reductases (metabolism)
  • Kinetics
  • Lanosterol (metabolism)
  • Liver Neoplasms, Experimental (metabolism)
  • Mevalonic Acid (metabolism)
  • Miconazole (pharmacology)
  • Rats

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