Effect of CH-123 on vascular cholesterol deposition in experimental atherosclerosis of rabbits.

Abstract

The effect of CH-123, a new antiarteriosclerotic pyrido-1,2a-pyramide derivate was checked in experimental atherosclerosis of rabbits. Cholesterol deposition was found to continue after 4-week cholesterol feeding even after the cholesterol level had returned to normal. This allowed to study the action of drugs in a phase dominated by lipid apposition to the vascular wall. In the experiments, clofibrate was used for reference. As judged by the lipid values in serum and aortic wall, CH-123 reduced substantially the deposition of lipids, mainly of cholesterol, into the aortic wall.

• Authors: S Virág, G Sebestyén, M Kovács, P Kapp
• Journal: Acta morphologica Academiae Scientiarum Hungaricae (Acta Morphol Acad Sci Hung) Vol. 27 Issue 1-2 Pg. 37-52 ( 1979) ISSN: 0001-6217 [Print] Hungary
• PMID: 506819 (Publication Type: Journal Article)

Chemical References

• Anticholesteremic Agents
• Lipids
• Pyrimidines
• Cholesterol

Topics

• Animals
• Anticholesteremic Agents (therapeutic use)
• Aorta (metabolism, pathology)
• Aortic Diseases (metabolism, pathology, prevention & control)
• Arteriosclerosis (metabolism, pathology, prevention & control)
• Cholesterol (blood, metabolism)
• Disease Models, Animal
• Drug Evaluation, Preclinical
• Lipids (blood)
• Pyrimidines (therapeutic use)
• Rabbits