| Abstract | Seventy-five women admitted with the symptom complex suggestive of pelvic inflammatory disease( PID) were started on a penicillin-aminoglycoside antibiotic regimen. An aminoglycoside, gentamicin or netilmicin (Schering-Plough), was chosen randomly and given parenterally. Forty-two patients received netilmicin and 33 received gentamicin for 5 days. Therapeutic response to the 2 antibiotic regimens was similar. Aminoglycosides have been associated with both nephrotoxicity and ototoxicity. Blood chemistries were studied in all patients. The only manifested toxicity was in 2 patients treated with gentamicin. Endometrial-endocervical cultures were obtained before and after therapy. The microbacteria isolated by standard culture techniques before therapy revealed Neisseria gonorrhoeae in 69% and 51% of the netilmicin and gentamicin groups, respectively; anaerobic organisms were cultured in about 75% of each group. |
| Authors | G Schnider, R A Birken, A N Poindexter |
| Journal | Obstetrics and gynecology
(Obstet Gynecol)
Vol. 54
Issue 5
Pg. 554-7
(Nov 1979)
ISSN: 0029-7844 UNITED STATES |
| PMID | 503379
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
|
| Chemical References |
- Gentamicins
- Netilmicin
- Penicillin G
|
| Topics |
- Acute Disease
- Adult
- Drug Therapy, Combination
- Female
- Gentamicins
(administration & dosage, adverse effects)
- Humans
- Netilmicin
(administration & dosage, adverse effects)
- Pelvic Inflammatory Disease
(drug therapy)
- Penicillin G
(administration & dosage, adverse effects)
|
