Immunological abnormalities and hydantoins.

Abstract	Various immunological features were measured in 20 patients with epilepsy who had received prolonged treatment with hydantoins. Immunoglobulin A (IgA) was shown to be absent or low in five patients, beta(1)C/A was low in 10 patients. Five patients showed negative reactions to skin tests, and two could not be sensitized to dinitrochlorobenzene. The corresponding features were normal in 14 control patients with epilepsy but without hydantoins. It is suggested that the hydantoins influence humoral immunity, whereas other immunosuppressant agents have been found to affect cellular immunity.
Authors	P J Grob, G E Herold
Journal	British medical journal (Br Med J) Vol. 2 Issue 5813 Pg. 561-3 (Jun 03 1972) ISSN: 0007-1447 [Print] England
PMID	5032783 (Publication Type: Journal Article)
Chemical References	Antigens Hydantoins Immunoglobulin A Immunoglobulin G Immunoglobulins Nitrobenzenes Phenytoin
Topics	Adult Agammaglobulinemia (chemically induced) Antigens Epilepsy (drug therapy) Female Humans Hydantoins (adverse effects, therapeutic use) Immunity, Cellular (drug effects) Immunoglobulin A Immunoglobulin G Immunoglobulins Male Middle Aged Nitrobenzenes Phenytoin (adverse effects, therapeutic use) Skin Tests

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