Immunogenicity of rabies virus inactivated by -propiolactone, acetylethyleneimine, and ionizing irradiation.

Abstract

Ionizing radiation, beta-propiolactone, and acetylethyleneimine were compared for their ability as virus-inactivating agents for the preparation of rabies vaccine. Each agent reduced viral infectivity exponentially; ionizing radiation also destroyed viral hemagglutinin. The vaccine prepared by ionizing radiation was equal or superior to that prepared by beta-propiolactone in its ability to protect mice from rabies infection. The acetylethyleneimine-treated vaccine was a less potent immunogen.

• Authors: T J Wiktor, H G Aaslestad, M M Kaplan
• Journal: Applied microbiology (Appl Microbiol) Vol. 23 Issue 5 Pg. 914-8 (May 1972) ISSN: 0003-6919 [Print] United States
• PMID: 5031561 (Publication Type: Journal Article)

Chemical References

• Acetates
• Antigens, Viral
• Cobalt Isotopes
• Ethylenes
• Hemagglutinins, Viral
• Heterocyclic Compounds
• Imines
• Lactones
• Propionates
• Rabies Vaccines

Topics

• Acetates (pharmacology)
• Animals
• Antigens, Viral (analysis)
• Cell Line (microbiology)
• Cobalt Isotopes
• Complement Fixation Tests
• Cricetinae
• Ethylenes (pharmacology)
• Hemagglutination Tests
• Hemagglutinins, Viral (analysis)
• Heterocyclic Compounds (pharmacology)
• Imines (pharmacology)
• Kidney
• Lactones (pharmacology)
• Mice
• Propionates (pharmacology)
• Rabies (prevention & control)
• Rabies Vaccines
• Rabies virus (drug effects, immunology, pathogenicity, radiation effects)
• Radiation Effects
• Virus Cultivation