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Phenacetin-induced hemolytic anemia.

Abstract
The hematological features of phenacetin-induced hemolytic anemia are presented in order to make the physician aware of the abnormalities which suggest the use of an oxidant drug. The presence of "bitten out" red cells is the commonest initial clue to the existence of drug-induced hemolytic anemia. The diagnosis is confirmed by the demonstration of Heinz bodies and sulfhemoglobinemia. Early recognition of this form of drug-abuse may avert the development or progression of analgesic nephropathy.
AuthorsJ Millar, R Péloquin, N K De Leeuw
JournalCanadian Medical Association journal (Can Med Assoc J) Vol. 106 Issue 7 Pg. 770-5 (Apr 08 1972) ISSN: 0008-4409 [Print] Canada
PMID5016923 (Publication Type: Journal Article)
Chemical References
  • Hemoglobins
  • Methemoglobin
  • Sulfhemoglobin
  • Glucosephosphate Dehydrogenase
  • Glutathione Reductase
  • Phenacetin
  • Glutathione
Topics
  • Adult
  • Aged
  • Anemia, Hemolytic (blood, chemically induced, complications)
  • Erythrocytes (analysis, enzymology)
  • Female
  • Glucosephosphate Dehydrogenase (blood)
  • Glutathione (blood)
  • Glutathione Reductase (blood)
  • Glycolysis
  • Heinz Bodies
  • Hemoglobins (analysis, metabolism)
  • Humans
  • Male
  • Methemoglobin (analysis)
  • Middle Aged
  • Phenacetin (adverse effects, therapeutic use)
  • Stomach Ulcer (complications)
  • Sulfhemoglobin (analysis)

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