Abstract |
Laboratory testing of animals is the principal method used to identify chemical carcinogens. However conflicting results are often obtained. This is emphasized in a cross-comparison of 6 aldrin- dieldrin studies; 3 were positive for tumor induction and 3 were negative. Four components of the assays are examined: husbandry, compound administration, observation, and interpretation of results.
|
Authors | D L Ritper |
Journal | Journal - Association of Official Analytical Chemists
(J Assoc Off Anal Chem)
Vol. 62
Issue 4
Pg. 900-3
(Jul 1979)
ISSN: 0004-5756 [Print] United States |
PMID | 500539
(Publication Type: Comparative Study, Journal Article)
|
Chemical References |
- Carcinogens
- Dieldrin
- Aldrin
|
Topics |
- Aldrin
(administration & dosage, toxicity)
- Animal Husbandry
- Animals
- Carcinogens
- Dieldrin
(administration & dosage, toxicity)
- Drug Evaluation, Preclinical
(methods)
- Mice
- Rats
- Research Design
|