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Comparison of carcinogenicity studies with aldrin and dieldrin.

Abstract
Laboratory testing of animals is the principal method used to identify chemical carcinogens. However conflicting results are often obtained. This is emphasized in a cross-comparison of 6 aldrin-dieldrin studies; 3 were positive for tumor induction and 3 were negative. Four components of the assays are examined: husbandry, compound administration, observation, and interpretation of results.
AuthorsD L Ritper
JournalJournal - Association of Official Analytical Chemists (J Assoc Off Anal Chem) Vol. 62 Issue 4 Pg. 900-3 (Jul 1979) ISSN: 0004-5756 [Print] United States
PMID500539 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Carcinogens
  • Dieldrin
  • Aldrin
Topics
  • Aldrin (administration & dosage, toxicity)
  • Animal Husbandry
  • Animals
  • Carcinogens
  • Dieldrin (administration & dosage, toxicity)
  • Drug Evaluation, Preclinical (methods)
  • Mice
  • Rats
  • Research Design

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