Abstract |
Chromatographic studies and microbiological assays show that, after oral administration, cephaloglycin is partially converted in man to a biologically active metabolite desacetylcephaloglycin. The antibacterial activity of this metabolite compared to that of cephaloglycin is equivalent against gram-positive organisms but is lower against gram-negative bacilli. Successful therapy of urinary tract infections with cephaloglycin must be mainly attributed to the antibacterial activity of this metabolite. At the present time, it is not possible to assess what influence low amounts of unaltered cephaloglycin have on the outcome of therapy.
|
Authors | W E Wick, W E Wright, H V Kuder |
Journal | Applied microbiology
(Appl Microbiol)
Vol. 21
Issue 3
Pg. 426-34
(Mar 1971)
ISSN: 0003-6919 [Print] United States |
PMID | 4994901
(Publication Type: Comparative Study, Journal Article)
|
Chemical References |
|
Topics |
- Administration, Oral
- Animals
- Bacillus subtilis
(drug effects)
- Bacteria
(drug effects)
- Biological Assay
- Cephalosporins
(administration & dosage, blood, metabolism, pharmacology, urine)
- Chromatography, Paper
- Disease Models, Animal
- Drug Resistance, Microbial
- Drug Stability
- Human Experimentation
- Humans
- Male
- Mice
- Microbial Sensitivity Tests
- Sarcina
(drug effects)
- Species Specificity
- Temperature
- Urinary Tract Infections
(drug therapy)
|