HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Metabolism of lysolecithin in vivo: effects of hyperlipemia and atherosclerosis in squirrel monkeys.

Abstract
We have studied the effect of long-term hyperlipemia and atherosclerosis in squirrel monkeys on the metabolism of lysolecithin-(14)C (1-palmitoyl-1'-(14)C sn-glycerol 3-phosphorylcholine) in order to explain elevated plasma and arterial concentrations of lysolecithin. The die-away curves of lysolecithin-(14)C from plasma and the timing of appearances of other (14)C-labeled moieties in plasma and other tissues demonstrated a complex pattern of metabolic reactions. There was a rapid equilibration of specific activities of lysolecithin of plasma, liver, and aortic intima plus inner media. The specific activities of lecithin peaked first in liver, then in plasma, and rose slowly in aortic intima plus inner media. The appearance of lecithin-(14)C in heart and skeletal muscle was also slower than in the liver and some other tissues. Triglycerides, and to a lesser extent, cholesteryl esters contained radioactivity. The concentrations of aortic lysolecithin in the atherosclerotic aortas were several times greater than comparable values for control aortas, and the time of equilibration of plasma and aorta lysolecithin-(14)C was much greater for the atherosclerotic group. The quantities of lysolecithin in plasma and in the pool of which the plasma was a part, were increased with hyperlipemia and atherosclerosis, as was the rate of lysolecithin production in the fast pool. Hyperlipemia was also associated with an early increase in plasma lecithin:cholesterol acyltransferase (LCAT) activity in vitro. Furthermore, nutritional hyperlipemia influenced the distribution of lysolecithin-(14)C and lecithin-(14)C between different plasma lipoproteins. The increase in concentrations of lysolecithin in the aorta occurred more slowly than that in plasma after we had induced hyperlipemia in the monkeys.
AuthorsO W Portman, P Soltys, M Alexander, T Osuga
JournalJournal of lipid research (J Lipid Res) Vol. 11 Issue 6 Pg. 596-604 (Nov 1970) ISSN: 0022-2275 [Print] United States
PMID4994121 (Publication Type: Journal Article)
Chemical References
  • Carbon Isotopes
  • Esters
  • Lysophosphatidylcholines
  • Phosphatidylcholines
  • Triglycerides
  • Cholesterol
  • Acyltransferases
  • Phospholipases
Topics
  • Acyltransferases (metabolism)
  • Animals
  • Aorta (analysis)
  • Arteriosclerosis (metabolism)
  • Carbon Isotopes
  • Cholesterol (metabolism)
  • Chromatography, Thin Layer
  • Diet, Atherogenic
  • Esters (metabolism)
  • Female
  • Haplorhini
  • Hyperlipidemias (enzymology, metabolism)
  • Injections, Intravenous
  • Kinetics
  • Liver (metabolism)
  • Lysophosphatidylcholines (administration & dosage, blood, metabolism)
  • Muscles (metabolism)
  • Myocardium (metabolism)
  • Phosphatidylcholines (analysis, blood)
  • Phospholipases
  • Time Factors
  • Triglycerides (metabolism)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: