Comparative study in angiocardiography in children, evaluating the side-effects of non-ionic and ionic contrast media.

Abstract

The study concerns 127 consecutive patients, presenting congenital heart disease, with an age distribution from neonatal to 15 years (mean 5 years). With non-ionic Amipaque, 164 injections were performed, with ionic Isopaque Coronar 81. Isopaque Coronar caused in 51% of the cases a clear discomfort for the patient; with Amipaque the side-effects were reduced to 9% (p less than 0.001). The mean body temperature rise with Amipaque was only 0.09 degrees C, against 0.28 degrees C with Isopaque Coronar (p less than 0.001). The changes in the heart rate reached 8.35% with Amipaque and 15.2% with Isopaque Coronar (p less than 0.001). Amipaque caused a mean of 1.8 extrasystoles per injection; Isopaque Coronar 2.2 (p less than 0.05). The quality of the angiogram with Amipaque was quite better than with Isopaque Coronar (p less than 0.0025). The non-ionic Amipaque is a much safer and better tolerated compound that the ionic Isopaque Coronar for paediatric angiocardiography.

• Authors: M Kunnen, A Devloo-Blancquaert
• Journal: Diagnostic imaging (Diagn Imaging) Vol. 48 Issue 4 Pg. 228-34 ( 1979) ISSN: 0378-9837 [Print] Switzerland
• PMID: 498918 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Drug Combinations
• Iodobenzoates
• Meglumine
• Metrizoic Acid
• Metrizamide
• methylglucamine metrizoate

Topics

• Adolescent
• Angiocardiography
• Blood Circulation (drug effects)
• Blood Pressure (drug effects)
• Body Temperature (drug effects)
• Child
• Child, Preschool
• Drug Combinations
• Heart Defects, Congenital (diagnostic imaging)
• Heart Rate (drug effects)
• Humans
• Infant
• Infant, Newborn
• Iodobenzoates (adverse effects)
• Meglumine (adverse effects, analogs & derivatives)
• Metrizamide (adverse effects)
• Metrizoic Acid (adverse effects, analogs & derivatives)
• Pulmonary Circulation (drug effects)