Cefamandole kinetics in uremic patients undergoing hemodialysis.

Abstract

A single intravenous 15 mg/kg dose of cefamandole was given to 6 patients in chronic renal failure before hemodialysis, and 3 were examined during an interdialysis period. Mean cefamandole clearance by hemodialysis was 24 +/- 12 ml/min; 35 +/- 15% of the dose was recovered in the dialysate. The cefamandole half-life (1 1/2) on dialysis was 4.0 +/- 0.29 hr; off dialysis it was 13.9 +/- 4.2 hr. High urine concentrations of cefamandole in these patients suggests usefulness in urinary tract infection.

• Authors: J G Gambertoglio, N S Aziz, E T Lin, H Grausz, J L Naughton, L Z Benet
• Journal: Clinical pharmacology and therapeutics (Clin Pharmacol Ther) Vol. 26 Issue 5 Pg. 592-9 (Nov 1979) ISSN: 0009-9236 [Print] United States
• PMID: 498702 (Publication Type: Journal Article)

Chemical References

• Cephalosporins
• Cefamandole
• Creatinine

Topics

• Adult
• Cefamandole (metabolism)
• Cephalosporins (metabolism)
• Creatinine (metabolism)
• Female
• Hematocrit
• Humans
• Kinetics
• Male
• Middle Aged
• Renal Dialysis
• Uremia (metabolism)