Formation of adducts of parthenin and related sesquiterpene lactones with cysteine and glutathione.

Abstract

Parthenin, the major sesquiterpene lactone of Parthenium hysterophorus, a weed responsible for dermatitis in man is primarily restricted to leaf and stem trichomes. Parthenin forms a monoadduct with L-cysteine through the alpha-methylene group of the gamma-lactone and a biadduct with the endocyclic double bond on the cyclopentenone ring. Studies with other sesquiterpene lactones support the view that the types of adducts formed are correlated with the biological activity of the sesquiterpene lactones.

• Authors: A K Picman, E Rodriguez, G H Towers
• Journal: Chemico-biological interactions (Chem Biol Interact) Vol. 28 Issue 1 Pg. 83-9 ( 1979) ISSN: 0009-2797 [Print] Ireland
• PMID: 498366 (Publication Type: Journal Article)

Chemical References

• Allergens
• Lactones
• Sesquiterpenes
• parthenin
• Glutathione
• Cysteine

Topics

• Allergens
• Chemical Phenomena
• Chemistry
• Cysteine
• Glutathione
• Lactones
• Sesquiterpenes