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Induction of hepatic neoplastic lesions in mice with a single dose of hycanthone methanesulfonate after partial hepatectomy.

Abstract
Experiments were designed to determine whether hycanthone methanesulfonate (1-([2-(diethylamino)ethyl]amino)-4-(hydroxymethyl)thioxanthen-9-one monomethanesulfonate), an antischistosomal drug, and its analog, IA-4-N-oxide (8-chloro-2-[2-(diethylamino)ethyl]-2H-[1]benzothiopyrano[4,3,2-cd]indazole 5-methanol monomethanesulfonate), will induce neoplastic lesions in the livers of mice not infected with Schistosoma mansoni. All the mice received a single i.m. injection of hycanthone methanesulfonate (76 mg/kg), IA-4-N-oxide (80 mg/kg), or an equivalent volume of the solvent, 0.9% NaCl solution, 42 hr after partial hepatectomy. Of the mice receiving hycanthone methanesulfonate and living 200 days or longer, hepatocellular carcinoma was seen in 11.5% and liver sarcoma was seen in 4.2%. This type of malignant neoplasm was not seen in the animals receiving either IA-4-N-oxide or 0.9% NaCl solution. In addition, mice receiving hycanthone methanesulfonate showed a significantly higher incidence of both type 1 (43% compared to 21% in controls) and type 2 (21% compared to 12% in controls) hepatocyte neoplasms. Mice receiving IA-4-N-oxide showed no increased incidence of neoplasms.
AuthorsH Tsuda, D S Sarma, S Rajalakshmi, J Zubroff, E Farber, R P Batzinger, Y N Cha, E Bueding
JournalCancer research (Cancer Res) Vol. 39 Issue 11 Pg. 4491-6 (Nov 1979) ISSN: 0008-5472 [Print] United States
PMID498081 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Thioxanthenes
  • Hycanthone
Topics
  • Animals
  • Hepatectomy
  • Hycanthone (adverse effects)
  • Liver Neoplasms (chemically induced, pathology)
  • Liver Neoplasms, Experimental (chemically induced)
  • Liver Regeneration
  • Male
  • Mice
  • Precancerous Conditions (chemically induced)
  • Sarcoma, Experimental (chemically induced)
  • Thioxanthenes (adverse effects)
  • Time Factors

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