Abstract |
Experiments were designed to determine whether hycanthone methanesulfonate (1-([2-(diethylamino)ethyl]amino)-4-(hydroxymethyl)thioxanthen-9-one monomethanesulfonate), an antischistosomal drug, and its analog, IA-4-N-oxide (8-chloro-2-[2-(diethylamino)ethyl]-2H-[1]benzothiopyrano[4,3,2-cd] indazole 5- methanol monomethanesulfonate), will induce neoplastic lesions in the livers of mice not infected with Schistosoma mansoni. All the mice received a single i.m. injection of hycanthone methanesulfonate (76 mg/kg), IA-4-N-oxide (80 mg/kg), or an equivalent volume of the solvent, 0.9% NaCl solution, 42 hr after partial hepatectomy. Of the mice receiving hycanthone methanesulfonate and living 200 days or longer, hepatocellular carcinoma was seen in 11.5% and liver sarcoma was seen in 4.2%. This type of malignant neoplasm was not seen in the animals receiving either IA-4-N-oxide or 0.9% NaCl solution. In addition, mice receiving hycanthone methanesulfonate showed a significantly higher incidence of both type 1 (43% compared to 21% in controls) and type 2 (21% compared to 12% in controls) hepatocyte neoplasms. Mice receiving IA-4-N-oxide showed no increased incidence of neoplasms.
|
Authors | H Tsuda, D S Sarma, S Rajalakshmi, J Zubroff, E Farber, R P Batzinger, Y N Cha, E Bueding |
Journal | Cancer research
(Cancer Res)
Vol. 39
Issue 11
Pg. 4491-6
(Nov 1979)
ISSN: 0008-5472 [Print] United States |
PMID | 498081
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
|
Chemical References |
|
Topics |
- Animals
- Hepatectomy
- Hycanthone
(adverse effects)
- Liver Neoplasms
(chemically induced, pathology)
- Liver Neoplasms, Experimental
(chemically induced)
- Liver Regeneration
- Male
- Mice
- Precancerous Conditions
(chemically induced)
- Sarcoma, Experimental
(chemically induced)
- Thioxanthenes
(adverse effects)
- Time Factors
|