[Inhibition of concanavalin A and phytohemagglutinine P mediated agglutination of L 1210 cells by different azomethines and possible relations to their cytostatic activity (author's transl)].

Abstract

Compounds of a special azomethine type have been tested on their activity against concanavalin A and phytohemagglutinine P mediated agglutination of leukemia L 1210 cells. With exception of two compounds possessing a bis-(beta-hydroxyethyl) amino group at the phenyl moiety in para-position to the azomethine group all substances considerable inhibited agglutination of L 1210 cells. In vitro active concentrations are also obtained in animal experiments at least for a short time at the site of injection (i.p.) The importance of cellular reactions for effectivity in vivo is discussed.

• Authors: W Gutsche, W Schulze, K Augsten, W Jungstand, K Wohlrabe, L Wollweber
• Journal: Archiv fur Geschwulstforschung (Arch Geschwulstforsch) Vol. 49 Issue 4 Pg. 311-24 ( 1979) ISSN: 0003-911X [Print] Germany
• Vernacular Title: Hemmung der durch Concanavalin A und Phytohämagglutinin P vermittelten Agglutination von L 1210-Zellen mit verschiedenen Azomethinen und mögliche Beziehungen zu deren zytostatischer Wirksamkeit.
• PMID: 496569 (Publication Type: English Abstract, Journal Article)

Chemical References

• Phytohemagglutinins
• Schiff Bases
• Concanavalin A

Topics

• Agglutination (drug effects)
• Animals
• Concanavalin A (pharmacology)
• Female
• In Vitro Techniques
• Leukemia L1210 (drug therapy)
• Male
• Mice
• Neoplasm Transplantation
• Phytohemagglutinins (pharmacology)
• Schiff Bases (pharmacology, therapeutic use)