Abstract |
In two previous studies the effects of topically applied 1% and 0.2% solutions of bupranolol on intraocular pressure were investigated in 21 and respectively 20 eyes with chronic uncomplicated open-angle glaucoma.--As early as 30 minutes after both solutions a very significant pressure drop, without concomittant pupillary reaction, was recorded. The 1% bupranolol solution was less well tolerated and caused some ocular irritation. The present study was therefore initiated in order to find out whether a 0.2% solution of bupranolol would yield significantly different results in comparison with the former.--Statistical evaluation, based on variance analysis linked with multiple t-tests, showed a barely significant difference between the pressure-lowering effects of the 1% and 0.2% solutions after one hour, whereas after 2 hours the difference became clearly significant in favour of the 0.2% solution. Furthermore, the 0.2% solution clearly showed a tendency to prolonged duration of effect, beyond the two-hour observation time. It therefore seems justified to supplement the present findings by long-term studies aimed at assessing optimal concentrations of the drug on the one hand, and its long-acting properties on the other. In this way, bupranolol is likely to gain recognition as an antiglaucomatous agent.
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Authors | I Oancea, V Trif |
Journal | Klinische Monatsblatter fur Augenheilkunde
(Klin Monbl Augenheilkd)
Vol. 174
Issue 5
Pg. 739-44
(May 1979)
ISSN: 0023-2165 [Print] Germany |
Vernacular Title | Uber die Drucksenkung mit Bupranolol in wässriger Lösung beim chronischen Glaucoma simplex. |
PMID | 491450
(Publication Type: Comparative Study, English Abstract, Journal Article)
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Chemical References |
- Ophthalmic Solutions
- Propanolamines
- Bupranolol
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Topics |
- Aged
- Bupranolol
(administration & dosage)
- Chronic Disease
- Dose-Response Relationship, Drug
- Female
- Glaucoma
(drug therapy, physiopathology)
- Humans
- Intraocular Pressure
(drug effects)
- Male
- Middle Aged
- Ophthalmic Solutions
- Propanolamines
(administration & dosage)
- Tonometry, Ocular
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